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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACHE
All Species:
22.42
Human Site:
S493
Identified Species:
37.95
UniProt:
P22303
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22303
NP_000656.1
614
67796
S493
F
G
I
P
L
D
P
S
R
N
Y
T
A
E
E
Chimpanzee
Pan troglodytes
XP_516857
643
72946
R522
F
G
L
P
L
E
R
R
D
N
Y
T
K
A
E
Rhesus Macaque
Macaca mulatta
NP_001121560
614
67754
S493
F
G
I
P
L
D
P
S
R
N
Y
T
T
E
E
Dog
Lupus familis
XP_546946
611
67308
S490
F
G
L
P
L
E
P
S
L
N
Y
T
A
E
E
Cat
Felis silvestris
Mouse
Mus musculus
P21836
614
68150
S493
F
G
L
P
L
D
P
S
L
N
Y
T
T
E
E
Rat
Rattus norvegicus
P37136
614
68178
S493
F
G
L
P
L
D
P
S
L
N
Y
T
V
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505841
602
68511
R481
F
G
L
P
L
E
R
R
V
N
Y
T
K
A
E
Chicken
Gallus gallus
P36196
767
83002
R648
F
G
L
P
L
E
P
R
N
N
Y
T
R
E
E
Frog
Xenopus laevis
NP_001121332
600
68177
N479
F
G
L
P
L
V
A
N
L
N
Y
N
P
Q
E
Zebra Danio
Brachydanio rerio
Q9DDE3
634
71980
R510
F
G
L
P
L
E
K
R
L
N
Y
T
A
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07140
649
71767
S533
F
G
Q
P
L
N
N
S
L
Q
Y
R
P
V
E
Honey Bee
Apis mellifera
XP_393751
657
73886
T519
F
G
E
P
L
D
P
T
K
G
Y
T
P
E
E
Nematode Worm
Caenorhab. elegans
P38433
620
71415
K483
F
G
E
P
L
N
Q
K
R
F
N
Y
T
D
E
Sea Urchin
Strong. purpuratus
XP_782113
508
56946
E405
A
I
A
F
Q
Y
T
E
W
L
A
P
H
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
99.5
92.8
N.A.
88.4
88.5
N.A.
50.6
47.9
59.6
60
N.A.
34.3
39.8
41.2
37.7
Protein Similarity:
100
66.8
99.6
96
N.A.
93
93.6
N.A.
68.2
58
73.4
73.6
N.A.
51.4
56.9
56.9
51.6
P-Site Identity:
100
53.3
93.3
80
N.A.
80
80
N.A.
53.3
66.6
46.6
66.6
N.A.
46.6
66.6
40
0
P-Site Similarity:
100
66.6
93.3
93.3
N.A.
86.6
86.6
N.A.
66.6
80
66.6
80
N.A.
53.3
80
53.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
0
8
0
0
0
8
0
22
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
36
0
0
8
0
0
0
0
15
0
% D
% Glu:
0
0
15
0
0
36
0
8
0
0
0
0
0
58
93
% E
% Phe:
93
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
93
0
0
0
0
0
0
0
8
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
8
15
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
8
8
8
0
0
0
15
0
0
% K
% Leu:
0
0
58
0
93
0
0
0
43
8
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
15
8
8
8
72
8
8
0
0
0
% N
% Pro:
0
0
0
93
0
0
50
0
0
0
0
8
22
0
8
% P
% Gln:
0
0
8
0
8
0
8
0
0
8
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
15
29
22
0
0
8
8
0
0
% R
% Ser:
0
0
0
0
0
0
0
43
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
8
8
0
0
0
72
22
0
0
% T
% Val:
0
0
0
0
0
8
0
0
8
0
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
86
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _